| Attribute | Details |
|---|---|
| Chemical Name | Sildenafil Citrate |
| Dosage Forms | 25mg, 50mg, 100mg |
| Function | Treats Erectile Dysfunction |
| Onset Time | 30 to 60 minutes |
| Learn More About Malegra | |
Chemical Structure
Sildenafil citrate, the active compound in Malegra, is a potent phosphodiesterase type 5 inhibitor. Its molecular formula is C22H30N6O4S, consisting of 22 carbon atoms, 30 hydrogen atoms, 6 nitrogen atoms, 4 oxygen atoms, and a sulfur atom. This heterocyclic compound contains a pyrazolopyrimidinone core that facilitates its interaction with PDE5 enzymes. By inhibiting PDE5, sildenafil enhances nitric oxide effects, promoting smooth muscle relaxation and increased blood flow in the corpus cavernosum.
The three-dimensional structure of sildenafil citrate features aromatic and aliphatic rings. Its conformation allows it to fit precisely into the PDE5 active site. This fit stabilizes the inhibitor-enzyme complex, prolonging its effect. As a result, Malegra effectively assists in achieving and maintaining erections.
Dosage Information
Malegra is available in doses of 25mg, 50mg, and 100mg. The initial dose usually recommended is 50mg, taken approximately one hour before sexual activity. The dosage may be adjusted to 25mg or 100mg based on efficacy and tolerance. Patients should not exceed one dose within a 24-hour period.
The medication is taken orally with water. Consuming a heavy meal or alcohol before taking Malegra may delay its onset. Adjustments might be necessary for individuals with hepatic or renal impairment. Always consult with a healthcare provider to determine the appropriate dose.
Malegra Precautions
Before initiating Malegra therapy, consider potential interactions. Patients with cardiovascular conditions, anatomical penile deformation, or predisposition to priapism require careful evaluation. Concomitant use with nitrates or guanylate cyclase stimulators poses significant risk and is contraindicated.
Assess all concurrent medications to avoid adverse reactions. Alpha-blockers may cause symptomatic hypotension. Cytochrome P450 3A4 inhibitors can elevate sildenafil plasma levels, necessitating dosage adjustments. Discuss any concerns with a qualified healthcare professional.
Pregnancy and Breastfeeding
Malegra is not intended for use in women. Its safety during pregnancy or breastfeeding remains unexplored. Animal studies on sildenafil have not shown direct harm to fertility. However, its role in female physiology and potential neonatal impacts are unknown. Women of childbearing potential should refrain from using Malegra without medical advice.
Any administration in clinical research involving pregnant or breastfeeding women must follow strict ethical guidelines. Such studies require thorough risk assessments and informed consent.
Toxicity
Overdosage of sildenafil 100mg can lead to severe consequences. Symptoms include prolonged erections, dizziness, or vision disturbances. In case of overdose, seek immediate medical attention. Symptomatic and supportive measures are employed in treatment. Hemodialysis does not significantly remove sildenafil from the body due to high protein binding.
Standard therapeutic doses are well tolerated. Common adverse effects may include headache, flushing, dyspepsia, or nasal congestion. Rare but serious events involve cardiac or ophthalmic complications. Any unusual symptoms warrant discontinuation and further evaluation.
Malegra for Sale Online
Purchasing Malegra online requires caution. Ensure transactions are through legitimate pharmacies. Verify authenticity and licensing to avoid counterfeit products. Counterfeit medications pose health risks due to unknown ingredient composition and dosing inaccuracies.
Online platforms might offer convenience, but personal safety should remain a priority. Healthcare professionals advise against unauthorized online purchases. Always engage with certified and reputable sources for any pharmaceutical needs. For more detailed guidance on Malegra, consult resources like NCBI.
Malegra provides a viable option for managing erectile dysfunction. Its effectiveness and range of dosages accommodate diverse patient needs. Safety remains a critical aspect, emphasizing the importance of informed medical consultation before use.
| Parameter | Description |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Pharmacodynamics | Inhibits PDE5, increases cGMP |
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